This paper deals with the Paneitz-Branson operator in compact Riemannian manifolds with negative Yamabe invariant. We start off by providing a new criterion for the positivity of the Paneitz-Branson operator when the Yamabe invariant of the manifold is negative. Another result stated in this paper is about the existence of a metric on a manifold of dimension 5 such that the Paneitz-Branson operator has multiple negative eigenvalues. Finally, we provide new inequalities related to the upper bound of the mean value of the Q-curvature.

Keywords: Paneitz-Branson operator, Yamabe invariant, Q-curvature, Negative eigenvalues